Saudi Honey in The Treatment of Gastric Ulcers

Recent years have witnessed a rise in reports on the occurrence of gastric ulceration especially among young children and adults. This study investigated the mechanism by which two types of Saudi honey: Alnahal Aljawal honey (Wadi) or Bin Ghaithan honey (Talh) exerted their antiulcer potential in indomethacin-induced gastric ulceration. Four groups of rats were used: Group 1; Healthy controls, Group 2; Ulcerative animals, Group 3; Ulcerative + Wadi honey treatment, Group 4; Ulcerative + Talh honey treatment. The effects of oxidative stress were investigated using the following indicators: lipid peroxide (MDA, measured as malondialdehyde), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, reduced glutathione (GSH), gastric mucosal and superoxide dismutase (SOD). CRP content, IL-10, and plasma tumor necrosis factor-α were also evaluated. The stomach was also examined visually for macroscopic lesions in the glandular mucosa, and for histopathological changes as observed