TRANSLATIONAL APPLICATIONS OF EXOSOMAL PROTEOMICS IN PERSONALISED MEDICINE: USING DETAILED PROTEOMIC ANALYSIS OF EXOSOMES TO DEVELOP INDIVIDUALISED THERAPEUTIC STRATEGIES.

Abstract: Exosomal proteomics is becoming an indispensable asset in the advancement of personalised medicine, offering a non-invasive means of disease characterisation, biomarker identification, and therapy customisation. Exosomes - nanoscale extracellular vesicles secreted by nearly all cell types, encapsulate a complex cargo of proteins, lipids, metabolites, and nucleic acids that mirror the physiological or pathological condition of their cellular origin. Among these, the proteomic constituents offer critical insight into intracellular pathways, rendering them highly valuable for elucidating disease mechanisms and tailoring molecularly informed treatments.