Anticancer, anti-inflammatory, antioxidant and anti-Angiogenic activities of diosgenin isolated from Costus speciosus (Koen.)

Costus speciosus is an important medicinal plant widely used in several indigenous medicinal formulations. The present study was conducted to evaluate the in vitro anticancer, anti-inflammatory, antioxidant and anti-angiogenic activities of diosgenin isolated from C. speciosus (Koen.) Sm. The diosgenin isolated from C. speciosus by HPTLC. The results indicated that the treatment of HepG2 cells with the sample resulted in a cytotoxic effect as concluded from the IC50 value 32.62 μg/ml, while the treatment of MCF-7 cells resulted in high inhibition in the cell viability, and resulted in an IC50 value of 11.03μg/ ml. The levels of DR4 and caspase-3 were significantly increased (P