Saudi Honey In The Treatment Of Gastric Ulcers

Conference: 5th International Conference on Quality and Evidence Based in Prophetic Medicine

Keywords: Saudi Honey, Indomethacin, Gastric Ulcer, Lipid Peroxidation, Antioxidant, Anti-Inflammatory

Abstract

Recent years have witnessed a rise in reports on the occurrence of gastric ulceration especially among young children and adults. This study investigated the mechanism by which two types of Saudi honey: Alnahal Aljawal honey (Wadi) or Bin Ghaithan honey (Talh) exerted their antiulcer potential in indomethacin-induced gastric ulceration. Four groups of rats were used: Group 1; Healthy controls, Group 2; Ulcerative animals, Group 3; Ulcerative + Wadi honey treatment, Group 4; Ulcerative + Talh honey treatment. The effects of oxidative stress were investigated using the following indicators: lipid peroxide (MDA, measured as malondialdehyde), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, reduced glutathione (GSH), gastric mucosal and superoxide dismutase (SOD). CRP content, IL-10, and plasma tumor necrosis factor-α were also evaluated. The stomach was also examined visually for macroscopic lesions in the glandular mucosa, and for histopathological changes as observed using light microscope. Wadi or Talh honey significantly decreased the ulcer index, and completely protected the mucosa from lesions. Wadi or Talh honey also significantly increased the gastric mucosal levels of GSH, GPx, and SOD. In addition, the administration of Wadi or Talh honey decreased gastric mucosal MDA and plasma TNF-α, CRP content, and IL-10 concentrations. In conclusion, Wadi or Talh honey possibly exerted their antiulcer, potential via restoring the homeostasis and stabilizing the enzymatic (GPx and SOD) and non-enzymatic (GSH) antioxidants as well as reducing the levels of inflammatory cytokines (TNF-α, CRP content, IL-10 and, NF-κB activity), and inhibiting the lipid peroxidation in the gastric mucosa. Consequently, Wadi or Talh honey may be of beneficial therapy for patients diagnosed with gastric ulceration. Clinical studies need to be conducted to further support these findings.