GABAergic Dysregulation in Autism Spectrum Disorder: Collaborative Insights on Neurobiological Complexity

الملخص

  This paper synthesizes insights from two collaborative studies investigating GABAergic dysregulation in autism spectrum disorder (ASD). The study by Al-Otaish et al. (2018) explored amino acid profiles in 40 male children with ASD, revealing elevated GABA levels and altered glutamate/glutamine ratios. In parallel, El-Ansary et al. (2021) focused on GABAergic dysfunction and apoptotic markers in a cohort of 20 ASD children. Both studies underscored GABA's pivotal role in ASD neurobiology, emphasizing its potential as a diagnostic biomarker. ASD, characterized by intricate genetic, environmental, and neurobiological factors, exhibits a heterogeneous landscape. The reduction in plasma GABA levels, concurrent with heightened apoptotic markers, implicates GABAergic dysregulation in synaptic pathologies, offering novel insights into the disorder's complexity. Despite methodological limitations and modest sample sizes, these findings contribute significantly to understanding GABAergic function in ASD. Future research should prioritize larger cohorts, diverse demographics, and refined methodologies to enhance generalizability. Integrating GABAergic insights into a broader neurobiological framework, the precision medicine approach holds promise for personalized interventions. This collaborative effort advances the comprehension of GABAergic dysregulation in ASD, contributing to a mosaic of knowledge vital for navigating this heterogeneous neurodevelopmental disorder.

المراجع

1. Al-Otaish H, Al-Ayadhi L, Bjørklund G, Chirumbolo S, Urbina MA, El-Ansary A. Relationship between absolute and relative ratios of glutamate, glutamine and GABA and severity of autism spectrum disorder. Metab Brain Dis 2018; 33(3): 843–854. doi: 10.1007/s11011-018- 0186-6.
2. El-Ansary A, Zayed N, Al-Ayadhi L, Qasem H, Anwar M, Meguid NA, Bhat RS, Doşa MD, Chirumbolo S, Bjørklund G. GABA synaptopathy promotes the elevation of caspases 3 and 9 as pro- apoptotic markers in Egyptian patients with autism spectrum disorder. Acta Neurol Belg 2021; 121(2): 489-501. doi: 10.1007/s13760-019- 01226-z.